To Have and Have Not: Lauren Bacall & Humphrey Bogart
Far and Away: Nicole Kidman & Tom Cruise
Cleopatra: Elizabeth Taylor & Richard Burton
Daredevil : Ben Affleck & Jennifer Garner
Green Lantern: Blake Lively
Stage Beauty: Billy Crudup
Mr. & Mrs. Smith: Brad Pitt
It seems safe to name production of Mr. & Mrs. Smith as the moment when Brad Pitt's marriage to Jennifer Aniston imploded. Although Aniston cited "irreconcilable differences" in her divorce filing just months before the movie's premiere, Pitt later went on record as saying he "fell in love" while shooting the film with Angelina Jolie. Suddenly, the rumors of an on-set dalliance seemed to be true. Jolie also confirmed that sparks flew while filming, despite her hesitance to pursue a married man.
"It took until, really, the end of the shoot for us, I think, to realize that it might mean something more than we’d earlier allowed ourselves to believe," she said. "And both knowing that the reality of that was a big thing, something that was going to take a lot of serious consideration." One month after Aniston's filing, a paparazzo spotted Jolie and Pitt vacationing with Jolie's adoptive son, Maddox, in Africa. Just like that, Brangelina was born.
The Outlaw Josey Wales: Clint Eastwood
Clint Eastwood had his share of flings, but his most notorious was likely on the set of The Outlaw Josey Wales. Though he was married to Maggie Johnson at the time, Eastwood began a not-so-secret affair with costar Sondra Locke that eventually led to the two cohabitating.
The relationship, like his past extramarital dalliances, ended in failure and resentment, but it did lead to his divorce from Johnson. Locke later described their tempestuous relationship in her memoir, The Good, the Bad, and the Very Ugly.
By The Sea: Brad Pitt & Angelina Jolie
What goes up must come down, and Brangelina came down hard after 2015's By the Sea. At the time of the film's release, Jolie told the press that the movie - which chronicles the disintegration of a marriage - was a "test" of her marriage to Brad, but in hindsight, it seems more like a documentary.
Rumors flew during production about Jolie's "dark side" poisoning her relationship during filming, while Jolie herself confirmed that she butted heads with her husband on set. One year after the movie's release, Jolie filed for divorce.
The Misfits: Marilyn Monroe & Arthur Miller
Marilyn Monroe and playwright Arthur Miller had been married four years when they united professionally on the set of The Misfits, but the movie's pressures proved too much for the mismatched couple. Miller wrote the movie as a drama starring vehicle for Monroe but annoyed her with his constant rewrites and blatant sexism. According to Monroe's biography, The Passion and the Paradox, Monroe, who had dubbed Miller a "peaceful monster" at the beginning of their marriage, claimed that the movie's most interesting roles had gone to its male stars.
Add to that the fact that the pair were confined to the Nevada desert for months and Monroe's declining health, and it wasn't long before the couple divorced. The Misfits turned out to be the last movie that Marilyn Monroe and Clark Gable ever filmed before their respective deaths. Gable died 12 days after filming completed; Monroe died one year after the film was released. Some critics say the actress' performance in the film was the finest of her career.
Mary Shelley's Frankenstein: Kenneth Branagh
While Kenneth Branagh directed and starred in Mary Shelley's Frankenstein, he was one half of a reigning couple of early '90s British cinema. Branagh had been married to Emma Thompson for five years before production started but apparently couldn't overcome his attraction to his Frankenstein co-star Helena Bonham Carter.
Thompson divorced Branagh shortly after news broke of his affair with Bonham Carter, and has since made peace with the actress: "As Mike Nicholls once said, and I’ve picked it up because I think it’s such a wonderful phrase - all blood under the bridge. You can’t hold on to anything like that. I just think… pfft... It’s pointless. I haven’t got the energy for it. Helena and I made our peace years and years ago."
Dream House: Rachel Weisz
Rachel Weisz had been partnered with Black Swan director Darren Aronofsky for almost ten years when she began production on Dream House with Daniel Craig. The actor was engaged at the time of filming, but their attraction seemed undeniable.
Neither party claims that Dream House is the reason their respective relationships ended, but Weisz is candid about where she was going wrong before meeting Craig: "I worried about so many things and it was hard for me to feel happy or understand what made me happy. Once you reach your forties, you know where to look." Weisz and Craig went public shortly after filming ended, and married only seven months later.
House Of Wax: Chad Michael Murray
Teenaged jaws dropped across the country in 2006 when Nick Carter went on Ryan Seacrest's radio show and claimed that then-girlfriend Paris Hilton had hooked up with Chad Michael Murray while filming House of Wax in 2005. Even more scandalous was the fact that Murray was married to One Tree Hill co-star Sophia Bush at the time.
Murray and Bush, who had been married for all of five months when the news broke, quickly separated and then divorced a few months later. In 2014, Bush defended her divorce from Murray while still circumventing the Paris Hilton rumors: "We were two stupid kids who had no business being in a relationship in the first place. To all the other co-stars who've worked it out, more power to you."